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Selective Oxidative Decarboxylation of Amino Acids to Produce Industrially Relevant Nitriles by Vanadium Chloroperoxidase

Authors

  • Andrada But ,

    1. “Politehnica” University of Timisoara, Industrial Chemistry and Environmental Engineering Faculty, Piata Victoriei 2, 300006 Timisoara (Romania)
    2. Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
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  • Dr. Jérôme Le Nôtre,

    Corresponding author
    1. Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
    • Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
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  • Dr. Elinor L. Scott,

    Corresponding author
    1. Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
    • Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
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  • Prof. Ron Wever,

    1. Van't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, 1090 GD Amsterdam (The Netherlands)
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  • Prof. Johan P. M. Sanders

    1. Chair of Biobased Commodity Chemicals, Wageningen University, PO Box 17, 6700AA Wageningen (The Netherlands), Fax: (+31) 317-483011
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Abstract

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Industrial nitriles from biomass: Vanadium-chloroperoxidase is successfully used to transform selectively glutamic acid into 3-cyanopropanoic acid, a key intermediate for the synthesis of bio-succinonitrile and bio-acrylonitrile, by using a catalytic amount of a halide salt. This clean oxidative decarboxylation can be applied to mixtures of amino acids obtained from plant waste streams, leading to easily separable nitriles.

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