A General and Efficient Heterogeneous Gold-Catalyzed Hydration of Nitriles in Neat Water under Mild Atmospheric Conditions

Authors

  • Dr. Yong-Mei Liu,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Lin He,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Miao-Miao Wang,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Dr. Yong Cao,

    Corresponding author
    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
    • Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Dr. He-Yong He,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Kang-Nian Fan

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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Abstract

original image

Mild, efficient and general: Titania decorated with nanometer-sized gold particles acts as an efficient catalyst for the selective hydration of a wide range of chemically diverse nitriles into valuable amides in neutral water, under mild atmospheric conditions (see image). The process shows promise for a facile and direct one-pot synthesis of ε-caprolactam, an industrially important molecule, starting from 6-aminocapronitrile.

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