An Integrated Approach for the Production and Isolation of 5-Hydroxymethylfurfural from Carbohydrates

Authors

  • Svilen P. Simeonov ,

    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, 1049-001 Lisboa (Portugal), Av. Prof. Gama Pinto, 1649-019
    2. CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
    3. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G.Bonchev str., bl.9, 1113 Sofia (Bulgaria)
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  • Jaime A. S. Coelho ,

    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, 1049-001 Lisboa (Portugal), Av. Prof. Gama Pinto, 1649-019
    2. CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
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  • Prof. Carlos A. M. Afonso 

    Corresponding author
    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, 1049-001 Lisboa (Portugal), Av. Prof. Gama Pinto, 1649-019
    2. CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
    • Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, 1049-001 Lisboa (Portugal), Av. Prof. Gama Pinto, 1649-019
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Abstract

original image

Crystal clear: An integrated, simple, efficient, reusable, and scalable methodology for the dehydration of fructose to HMF offers outstanding yields and high purities. The method uses wet tetraethylammonium bromide as reaction medium, allowing the isolation of HMF by crystallization from the reaction medium. The process is also feasible starting from other carbohydrates, such as glucose, sucrose, or inulin.

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