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Keywords:

  • click chemistry;
  • flow chemistry;
  • microextraction;
  • microreactors;
  • novel process windows
Thumbnail image of graphical abstract

Avoiding the coppers: A continuous-flow synthesis for the CuI-catalyzed azide–alkyne cycloaddition reaction using [Cu(phenanthroline)(PPh3)2]NO3 as a homogeneous catalyst is developed (up to 92 % isolated yield). Elevated temperatures allow achieving full conversions and using lower catalyst loadings. Residual copper in the triazole compound is efficiently removed via an inline extraction process, employing aqueous EDTA as a copper scavenger.