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Communication
Copper(I)-Catalyzed Azide–Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit
Article first published online: 29 JUN 2012
DOI: 10.1002/cssc.201200323
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Varas, A. C., Noël, T., Wang, Q. and Hessel, V. (2012), Copper(I)-Catalyzed Azide–Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit. ChemSusChem, 5: 1703–1707. doi: 10.1002/cssc.201200323
Publication History
- Issue published online: 5 SEP 2012
- Article first published online: 29 JUN 2012
- Manuscript Revised: 21 MAY 2012
- Manuscript Received: 11 MAY 2012
Funded by
- Advanced European Research Council Grant. Grant Number: 267443
Keywords:
- click chemistry;
- flow chemistry;
- microextraction;
- microreactors;
- novel process windows
Avoiding the coppers: A continuous-flow synthesis for the CuI-catalyzed azide–alkyne cycloaddition reaction using [Cu(phenanthroline)(PPh3)2]NO3 as a homogeneous catalyst is developed (up to 92 % isolated yield). Elevated temperatures allow achieving full conversions and using lower catalyst loadings. Residual copper in the triazole compound is efficiently removed via an inline extraction process, employing aqueous EDTA as a copper scavenger.