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Keywords:

  • alcohols;
  • flow chemistry;
  • metal-free chemistry;
  • oxidation;
  • process intensification

Abstract

The selective oxidation of alcohols is a pivotal transformation within industrial and synthetic chemistry. In this contribution we use O2 as terminal oxidant and (H)NOx species as oxygen shuttle in order to mediate the oxidation of primary and secondary alcohols under the influence of a solid acid catalyst. Process optimization and intensification through the use of a continuous three-phase flow reactor is demonstrated. Space–time yields were found to increase by two orders of magnitude with respect to batch experiments, along with additional gains in selectivity and a decrease of N2O formation.