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Keywords:

  • alkynes;
  • cycloaddition;
  • homogeneous catalysis;
  • iridium;
  • isoindolines
Thumbnail image of graphical abstract

Iridium(III) catalysis provides a convenient and general method for the synthesis of isoindolines via [2+2+2] cycloaddition reactions of diynes and alkynes. The reaction proceeds smoothly in environmentally benign and non-distilled isopropyl alcohol, providing highly functionalized aromatic compounds in moderate to excellent yields.