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Practical and Efficient Iridium Catalysis for Benzannulation: An Entry To Isoindolines

Authors

  • Dr. Anne-Laure Auvinet,

    1. Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
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  • Dr. Mehdi Ez-Zoubir,

    1. Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
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  • Dr. Maxime R. Vitale,

    1. Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
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  • Dr. Jack A. Brown,

    1. GlaxoSmithKline, Epinova DPU, II TAU, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY (UK)
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  • Dr. Véronique Michelet,

    Corresponding author
    1. Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
    • Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
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  • Dr. Virginie Ratovelomanana-Vidal

    Corresponding author
    1. Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
    • Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France), Fax: (+33) 1-44071062
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Abstract

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Iridium(III) catalysis provides a convenient and general method for the synthesis of isoindolines via [2+2+2] cycloaddition reactions of diynes and alkynes. The reaction proceeds smoothly in environmentally benign and non-distilled isopropyl alcohol, providing highly functionalized aromatic compounds in moderate to excellent yields.

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