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DDQ-Catalyzed Oxidative C[BOND]O Coupling Of sp3 C[BOND]H Bonds With Carboxylic Acids

Authors

  • Hong Yi,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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    • These authors contributed equally to this work.

  • Qiang Liu,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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    • These authors contributed equally to this work.

  • Jie Liu,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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  • Ziqi Zeng,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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  • Yuhong Yang,

    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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  • Prof. Aiwen Lei

    Corresponding author
    1. The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
    2. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (PR China)
    • The College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072 (PR China), Fax: (+86) 27-68754672
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Abstract

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Da-ddy, DDQ: By using catalytic amounts of DDQ combined with MnO2 as oxidant, an efficient oxidative C[BOND]O coupling of benzylic sp3 C[BOND]H bonds with carboxylic acids affords a series of carboxylic esters in 70–98 % yields. A wide range of functional groups and various carboxylic acids are tolerated. The reaction involves both C[BOND]H functionalization and C[BOND]O bond formation.

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