C[BOND]C Cross-Coupling of Primary and Secondary Benzylic Alcohols Using Supported Gold-Based Bimetallic Catalysts

Authors

  • Xiang Liu,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Ran-Sheng Ding,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Lin He,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Dr. Yong-Mei Liu,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Dr. Yong Cao,

    Corresponding author
    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
    • Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Dr. He-Yong He,

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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  • Prof. Kang-Nian Fan

    1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774
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Abstract

original image

Clean alcohol–alcohol cross-coupling: A clean and efficient one-pot direct C[BOND]C cross-coupling of equimolar amounts of primary and secondary alcohols by a facile hydrogen autotransfer pathway is achieved over a robust and easily recovered hydrotalcite-supported Au–Pd bimetallic catalyst system. A variety of primary and secondary alcohols have been selectively converted into the corresponding β-alkylated ketones in good yields.

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