Cover Picture: Practical Synthesis of Photochromic Diarylethenes in Integrated Flow Microreactor Systems (ChemSusChem 2/2012)

Authors

  • Tatsuro Asai,

    1. The Research Association of Micro Chemical, Process Technology (MCPT) in Kyoto, Kyoto University, Kyoto, 615-8530 (Japan)
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  • Atsushi Takata,

    1. Yamada Chemical Co., Ltd. Minami-ku, Kyoto, 601-8105 (Japan)
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  • Dr. Aiichiro Nagaki,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Prof. Dr. Jun-ichi Yoshida

    Corresponding author
    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
    • Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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Abstract

original image

The synthesis of photochromic diarylethenes involves generating heteroaryllithium compounds by a halogen–lithium exchange reaction of heteroaryl halides, and subsequent reaction with octafluorocyclopentene. In a conventional batch macroreactor the reaction should be carried out at temperatures of −78 °C or lower, because heteroaryllithium compounds are often unstable and decompose at higher temperatures. The front cover features research by Jun-ichi Yoshida et al. (page 339), who report a practical method for the synthesis of photochromic diarylethenes by using integrated flow microreactor systems. Reactions can be conducted without using cryogenic conditions by virtue of effective temperature and residence-time control. Moreover, the synthesis of unsymmetrical diarylethenes, which is difficult to achieve using conventional batch macro systems, is accomplished.

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