Cofactor Regeneration: Second Nature for Silicon Nanowires The cover image illustrates the successful regeneration of NAD(P)H cofactors by using silicon nanowires under visible light, mimicking natural photosynthesis. The efficient light harvesting and utilization of solar energy is a key factor in natural photosynthesis, maintaining the viability of green plants and photosynthetic bacteria by converting solar energy into chemical energy. In natural photosynthesis, photoexcited electrons from photosynthetic reaction centers are passed along to regenerate reducing power in the form of NAD(P)H cofactors from their oxidized form. The Communication by Chan Beum Park and colleagues at the Korea Advanced Institute of Science and Technology and MIT, reported on page 2129, demonstrates that hydrogen-terminated silicon nanowires possess a high photocatalytic ability that is suitable for visible-light-driven regeneration of NAD(P)H and redox enzymatic synthesis towards biocatalyzed artificial photosynthesis.
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