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Integrated Chemo-Enzymatic Production of 5-Hydroxymethylfurfural from Glucose

Authors

  • Svilen P. Simeonov,

    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-019 (Portugal) and CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
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  • Jaime A. S. Coelho,

    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-019 (Portugal) and CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
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  • Prof. Carlos A. M. Afonso

    Corresponding author
    1. Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-019 (Portugal) and CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
    • Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-019 (Portugal) and CQFM, Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, 1049-001 Lisboa (Portugal)
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Abstract

original image

Sweets for my sweet: The production and isolation of 5-hydroxymethylfurfural (HMF) in high yield and purity is demonstrated by using a combination of glucose–fructose isomerization with sweetzyme in wet tetraethylammonium bromide (TEAB) and clean fructose dehydration to HMF catalyzed by using HNO3 under moderate conditions, which allow the reuse of any unreacted glucose and TEAB.

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