Organophosphorus Catalysis to Bypass Phosphine Oxide Waste

Authors

  • Dr. Henri A. van Kalkeren,

    1. Institute for Molecules and Materials, Radboud University of Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands)
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  • Dr. Floris L. van Delft,

    1. Institute for Molecules and Materials, Radboud University of Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands)
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  • Prof. Dr. Floris P. J. T. Rutjes

    Corresponding author
    1. Institute for Molecules and Materials, Radboud University of Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands)
    • Institute for Molecules and Materials, Radboud University of Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands)

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Abstract

The conversion of oxygen-containing compounds is often achieved by the use of phosphorus reagents. The newly formed phosphine oxide bond delivers the enthalpic gain that drives reactions, such as the Wittig, Mitsunobu, and Appel reaction, to completion. However, phosphine oxides are recognized as undesirable waste products and in the past decade several methods have emerged that address this issue by in situ regeneration of the phosphorus reagent. This Minireview outlines the two distinct strategies and underpinning research that led to these advances. The potential of the emerging field of phosphorus catalysis in chemistry is shown and new developments that may stimulate further research are described.

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