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Keywords:

  • asymmetric catalysis;
  • chirality;
  • flow chemistry;
  • peptides;
  • supported catalysts
Thumbnail image of graphical abstract

The front cover shows a flow system that operates with a highly effective immobilized peptidic catalyst, reported by Helma Wennemers and co-workers from the ETH Zürich, Switzerland on page 242. More than 600 turnovers and high stereoselectivities are achieved on a scale of >450 mmol (>100 g), without a significant drop of the activity or stereoselectivity of the immobilized peptidic catalyst. This high efficiency and sustainability of a flow system is unprecedented in the very active field of enamine catalysis and opens the way for more practical applications.