Inside Cover Picture: Rapid Trifluoromethylation and Perfluoroalkylation of Five-Membered Heterocycles by Photoredox Catalysis in Continuous Flow (ChemSusChem 6/2014)

Authors

  • Natan J. W. Straathof,

    1. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
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  • Hannes P. L. Gemoets,

    1. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
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  • Dr. Xiao Wang,

    1. Harvard NeuroDiscovery Center, Harvard Medical School and Brigham & Women's Hospital, 65 Landsdowne Street, Cambridge, MA 02139 (USA)
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  • Prof. Dr. Jaap C. Schouten,

    1. Department of Chemical Engineering and Chemistry, Chemical Reactor Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
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  • Prof. Dr. Volker Hessel,

    1. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
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  • Dr. Timothy Noël

    Corresponding author
    1. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
    2. Ghent University, Department of Organic Chemistry, Krijgslaan 281 (S4), 9000 Ghent (Belgium)
    • Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)===

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Abstract

original image

The Inside Cover picture shows how trifluoromethylated and perfluoroalkylated heterocycles can be prepared by continuous-flow photoredox catalysis utilizing [Ru(bpy)3] and blue light irradiation. Spectacular accelerations are observed in microreactors because of the homogeneous irradiation of the reaction sample and the optimal gas-liquid mass transfer. The mild reaction conditions should facilitate the implementation of this methodology in both academia and industry. More details can be found in the Communication by Noël et al. on page 1612 (DOI: 10.1002./cssc.201301282).

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