Dehydration of Different Ketoses and Aldoses to 5-Hydroxymethylfurfural (pages 1681–1687)
Robert-Jan van Putten, Jenny N. M. Soetedjo, Dr. Evgeny A. Pidko, Dr. Jan C. van der Waal, Prof. Dr. Emiel J. M. Hensen, Dr. Ed de Jong and Prof. Dr. Hero J. Heeres
Article first published online: 23 AUG 2013 | DOI: 10.1002/cssc.201300345
Ketose dries out: Hexose dehydration to 5-hydroxymethylfurfural is studied using different ketoses and aldoses. The reactivity of the different ketoses is found to be a function of the hydroxyl group orientation at the C3 and C4 positions. The results point to a dehydration mechanism involving cyclic intermediates. For aldoses, no influence of the hydroxyl group orientation is observed, indicating a different rate-determining step.