Antimicrobial Activity Against Hospital-related Pathogens of Dual Layer CuO/TiO2 Coatings Prepared by CVD


  • This work was partly supported by Framework 7 grant FP7 NMP CP-IP 214134-2 N2P “Flexible production technologies and equipment based on atmospheric pressure plasma processing for 3D nano-structured surfaces”. The authors would like to thank Professor F. J. (Eric) Bolton, Health Protection Agency, Manchester, for providing the cultures of hospital pathogens. This article is part of a special section on the CVD of TiO2 and Doped TiO2 Films.


Photocatalytically active films of TiO2/CuO grown by atmospheric pressure thermal (APT)CVD are investigated for activity against multiple antibiotic-resistant pathogens namely, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, vancomycin-resistant enterococci (VRE), and a recent isolate of methicillin-resistant Staphylococcus aureus (MRSA), that have been shown to persist in the hospital environment. The bacteria are killed by UVA irradiation of the photocatalyst with a >5 log kill within 4–6 h except for the MRSA where a 2–3 log kill is obtained after 6 h increasing to >5 log after 24 h. There is antimicrobial activity in the dark which is enhanced by irradiation with fluorescent light. There is also activity at 5 °C under UVA, but activity is lower when fluorescent light is used for illumination.