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LITERATURE CITED

  • 1
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    Aschele C, Debernardis D, Casazza S, Antonelli G, Tunesi G, Baldo C, Lionetto R, Maley F, Sobrero A. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy. J Clin Oncol 1999; 17: 17601770.
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    Etienne MC, Pivot X, Formento JL, Bensadoun RJ, Formento P, Dassonville O, Francoual M, Poissonnet G, Fontana X, Schneider M, Demard F, Milano G. A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil. Br J Cancer 1999; 79: 18641869.
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    van Triest B, Pinedo HM, van Hensbergen Y, Smid K, Telleman F, Schoenmakers PS, van der Wilt CL, van Laar JA, Noordhuis P, Jansen G, Peters GJ. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. Clin Cancer Res 1999; 5: 643654.
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    Mirjolet JF, Barberi Heyob M, Merlin JL, Marchal S, Etienne MC, Milano G, Bey P. Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity. Br J Cancer 1998; 78: 6268.
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    Chou TC, Talalay P. Application of the median-effect principle for the assessment of low dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. In: HarrapKR, ConnorsTA, editors. New avenues in developmental cancer chemotherapy. New York: Academic Press; 1987. p 3764.
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    Marchal S, Marchal C, Parache RM, Benjaafar N, Odda M, Leclerc A, Merlin JL, el Gueddarri B, Bey P. Combined flow cytometry and immunohistochemistry analyses for the assessment of nasopharyngeal carcinoma cell kinetics by in vivo bromodeoxyuridine infusion. Cytometry 1997; 29: 165172.
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    Pestalozzi BC, Peterson HF, Gelber RD, Goldhirsch A, Gusterson BA, Trihia H, Lindtner J, Cortes-Funes H, Simmoncini E, Byrne MJ, Golouh R, Rudenstam CM, Castiglione-Gertsch M, Allegra CJ, Johnston PG. Prognostic importance of thymidylate synthase expression in early breast cancer. J Clin Oncol 1997; 15: 19231931.
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    Poon PP, Storms RK. Thymidylate synthase is localized to the nuclear periphery in the yeast Saccharomyces cerevisiae. J Biol Chem 1994; 269: 83418347.
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    Berger SH, Barbour KW, Berger FG. A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line. Mol Pharmacol 1988; 34: 480484.
  • 36
    Johnson LF. Posttranscriptional regulation of thymidylate synthase gene expression. J Cell Biochem 1994; 54: 387392.
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    Ayusawa D, Shimizu K, Koyama H, Kaneda S, Takeishi K, Seno T. Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate. J Mol Biol 1986; 190: 559567.
  • 38
    Begg AC. The clinical status of Tpot as a predictor? Or why no tempest in the Tpot! [editorial; comment]. Int J Radiat Oncol Biol Phys 1995; 32: 15391541.
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    Haustermans K, Fowler J, Geboes K, Christiaens MR, Lerut A, van der Schueren E. Relationship between potential doubling time (Tpot), labeling index and duration of DNA synthesis in 60 esophageal and 35 breast tumors: is it worthwhile to measure Tpot? Radiother Oncol 1998; 46: 157167.
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    Zackrisson B, Gustafsson H, Stenling R, Flygare P, Wilson GD. Predictive value of potential doubling time in head and neck cancer patients treated by conventional radiotherapy. Int J Radiat Oncol Biol Phys 1997; 38: 677683.
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    Gilliland R, Williamson KE, Hamilton PW, Crockard A, Spence RA. DNA denaturation sensitivity may invalidate bromodeoxyuridine—DNA flow cytometric analysis of potential doubling times in colorectal tumours. Br J Surg 1997; 84: 242247.
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    Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, Stoumen AL, Pamukcu R, Ahnen DJ. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res 1997; 57: 24522459.
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    Tsurusawa M, Niwa M, Katano N, Fujimoto T. Flow cytometric analysis by bromodeoxyuridine/DNA assay of cell cycle perturbation of methotrexate-treated mouse L1210 leukemia cells. Cancer Res 1988; 48: 42884293.
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    Tonkinson JL, Marder P, Andis SL, Schultz RM, Gossett LS, Shih C, Mendelsohn LG. Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis. Cancer Chemother Pharmacol 1997; 39: 521531.
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