The significance of DNA measurements for the early detection of bronchial cell atypia

Authors

  • J. Ono,

    1. From the Institute of Tumor Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    2. Department of Surgery, Tokyo Medical College Hospital, 6-7-1 Nishishinjuku, Shinjuku-Ku, Tokyo, Japan
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  • Gert Auer M.D.

    Corresponding author
    1. From the Institute of Tumor Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    • Institute of Tumor Pathology, Karolinska Institute and Hospital, S-104 01 Stockholm 60 Sweden
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  • This work was Supported by the Swedish Cancer Society, the Japan Tobacco Monopoly Corporation, and the Tokyo Medical College Cancer Center.

Abstract

Investigations in an experimental model system and in clinical material indicate that squamous bronchial carcinoma is regularly preceded by the occurrence of bronchial cells with DNA values exceeding significantly the normal 4c region. The studies also show that cytomorphological methods do not allow the discrimination between milder forms of atypia and nonspecific cellular alterations. We describe a combined cytomorphological and cytochemical diagnostic procedure which facilitates the distinction between atypical squamous cells and nonspecific cellular changes in the bronchial tree.

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