This work was supported in part by NIH grant 2 R44 RR03015-02.
Article first published online: 8 MAR 2005
Copyright © 1990 Wiley-Liss, Inc.
Volume 11, Issue 3, pages 447–450, 1990
How to Cite
Gandler, W. and Shapiro, H. (1990), Logarithmic amplifiers. Cytometry, 11: 447–450. doi: 10.1002/cyto.990110317
An expanded discussion of logarithmic amplifiers is available from the first author.
- Issue published online: 21 JUN 2005
- Article first published online: 8 MAR 2005
- Dynamic range;
- coefficient of variation;
Logarithmic amplifiers (log amps), which produce an output signal proportional to the logarithm of the input signal, are widely used in cytometry for measurements of parameters that vary over a wide dynamic range, e.g., cell surface immunofluorescence. Existing log amp circuits all deviate to some extent from ideal performance with respect to dynamic range and fidelity to the logarithmic curve; accuracy in quantitative analysis using log amps therefore requires that log amps be individually calibrated. However, accuracy and precision may be limited by photon statistic and system noise when very low level input signals are encountered.