This article is a US government work and, as such, is in the public domain in the United States of America.
Phenotype and function of human T lymphocyte subsets: Consensus and issues†
Article first published online: 10 SEP 2008
Published 2008 Wiley-Liss, Inc.
Cytometry Part A
Special Issue: MASIR: Measurement of Antigen-Specific Immune Responses. 2008
Volume 73A, Issue 11, pages 975–983, November 2008
How to Cite
Appay, V., van Lier, R. A. W., Sallusto, F. and Roederer, M. (2008), Phenotype and function of human T lymphocyte subsets: Consensus and issues. Cytometry, 73A: 975–983. doi: 10.1002/cyto.a.20643
- Issue published online: 22 OCT 2008
- Article first published online: 10 SEP 2008
- Manuscript Accepted: 11 AUG 2008
- Manuscript Revised: 12 JUN 2008
- Manuscript Received: 2 APR 2008
- T cells;
In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley-Liss, Inc.