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LITERATURE CITED

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    Durban M, Harezlak J, Wand MP, Carroll RJ. Simple fitting of subject-specific curves for longitudinal data. Stat Med 2005; 24: 11531167.
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    Brinkman RR, Gasparetto M, Lee S-JJ, Ribickas AJ, Perkins J, Janssen W, Smiley R, Smith C. High-content flow cytometry and temporal data analysis for defining a cellular signature of graft-versus-host disease. Biol Blood Marrow Transplant 2007; 13: 691700.
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    Lo K, Brinkman RR, Gottardo R. Automated gating of flow cytometry data via robust model-based clustering. Cytometry A 2008; 73A: 321332.
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    Draper NR, Smith H. Applied Regression Analysis, ( 3rd ed). New York: Wiley; 1998.
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    Donnelly CA, Laird NM, Ware JH. Prediction and creation of smooth curves for temporally correlated longitudinal data. J Amer Stat Assoc 1995; 90: 984989.
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    R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN3-900051-07-0. 2008 www.R-project.org.
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    Gentleman R, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini A, Sawitzki G, Smith C, Smyth G, Tierney L, Yang YH, Zhang J. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80.
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    Pinheiro J, Bates D, DebRoy S, Sarkar D. the R Core team. nlme: linear and nonlinear mixed effects models. R package version 3.1–89. 2008.
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    Sarkar D. Lattice: Lattice Graphics. R package version 0.17–15. 2008.
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    Duong T, Hazelton ML. Plug-in bandwidth matrices for bivariate kernel density estimation. J Nonpar Stat 2003; 15: 1730.
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    Wand MP, Jones MC. Multivariate plug-in bandwidth selection. Comput Statist 1994; 9; 97116.
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    Duong T. ks: Kernel Smoothing. R package version 1.5.10. 2009.
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    Hyndman RJ. Computing and graphing highest density regions. Am Stat 1996; 50: 120126.