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Abstract

Sites of hypermethylation and demethylation of nuclear foci affected epigenetically by drugs or the environment show places of transcription modulation, i.e. activation or deactivation. In consequence, these changes may lead to differentiation or dedifferentiation of a cell. Gertych et al. quantitate in their sophisticated work these foci (dots within the triangles in the artist's rendering) and show that responses of seemingly similar cells (triangles) in a homogeneous cell culture are clearly varying in their number and extent of methylation sites. See the accompanying article on page 569 in this issue