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LITERATURE CITED

  • 1
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  • 2
    Unger C,Karner E,Treschow A,Stellan B,Felldin U,Concha H,Wendel M,Hovatta O,Aints A,Ahrlund-Richter L,Dilber MS. Lentiviral-mediated HoxB4 in human embryonic stem cells initiates early hematopoiesis in a dose-dependent manner but does not promote myeloid differentiation. Stem Cells 2008; 26: 24552466.
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    Wilson A,Murphy MJ,Oskarsson T,Kaloulis K,Betess MD,Oser GM,Pasche AC,Knabenhans C,MacDonald HR,Trumpp A. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 2004; 18: 27472763.
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    Baena E,Ortiz M,Martinez-A C,de Alboran IM. c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin-Sca-1+c-Kit- cell generation through p21. Exp Hematol 2007; 35: 13331343.
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    Laurenti E,Varnum-Finney B,Wilson A,Ferrero I,Blance-Bose WE,Ehninger A,Knoepfler PS,Cheng P-F,MacDonald HR,Eisenman RN,Bernstein ID,Trumpp A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 2008; 3: 611624.
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    Satoh Y,Matsumura I,Tanaka H,Ezoe S,Sugahara H,Mizuki M,Shibayama H,Ishiko E,Ishiko E,Ishiko J,Nakajima K,Kanakura Y. Roles for c-Myc in self-renewal of hematopoietic stem cells. J Biol Chem 2004; 279: 2498624993.
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    Tsai F-Y,Keller G,Kuo FC,Weiss M,Chen J,Rosenblatt M,Alt FW,Orkin SH. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994; 371: 221226.
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    Heyworth C,Gale K,Dexter M,May G,Enver T. A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal. Genes Dev. 1999; 13: 18471860.
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    Ezoe S,Matsumura I,Nakata S,Gale K,Ishihara K,Minegishi N,Machii T,Kitamura T,Yamamoto M,Enver T,Kanakura Y. GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21waf1 and p27kip1 proteins. Blood 2002; 100: 35123520.
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    Tipping AJ,Pina C,Castor A,Hong D,Rodrigues NP,Lazzari L,May GE,Jacobsen SEW,Enver T. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 2009; 113: 26612672.
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    Park I,Qian D,Kiel M,Becker MW,Pihalja M,Weissman IL,Morrison SJ,Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopietic stem cells. Nature 2003; 423: 302305.
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    Rizo A,Olthof S,Han L,Vellenga E,de Haan G,Schuringa JJ. Repression of BMI1 in normal and lekemic human CD34+ cells impairs self-renewal and induces apoptosis. Blood 2009; 114: 14981505.
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    Liakhovitskaia A,Gribi R,Stamateris E,Villain G,Jaffredo T,Wilkie R,Gilchrist D,Yang J,Ure J,Medvinsky A. Restoration of Runx1 expression in the Tie2 cell compartment rescues definitive haematopoietic stem cells and extends life of Runx1 knockout animals until birth. Stem Cells 2009; 27: 16161624.
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    Semerad CJ,Mercer EM,Inlay MA,Weissman IL,Murre C. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci USA 2009; 106: 19301935.
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    Zhang J,Grindley JC,Yin T,Jayasinghe S,He XC,Ross JT,Haug JS,Rupp D,Porter-Westpfall KS,Wiedemann LM,Wu H,Li L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 2006; 441: 518522.
  • 16
    Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA. AKT1 and AKT2 maintain hematopietic stem cell function by regulating reactive oxygen species. Blood 2010; 115: 40304038.
  • 17
    Reya T,Duncan AW,Ailles L,Domen J,Scherer DC,Willert K,Hintz L,Nusse R,Weissman IL. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003; 423: 409414.
  • 18
    Kim J,Kang Y,Park G,Kim M,Park Y,Kim H,Leem S,Chu I,Lee J,Jho E,Oh I. Identification of a stroma-mediated Wnt/β-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche. Stem Cells 2009; 27: 13181329.
  • 19
    Li G,Wang Z,Miskimen KL,Zhang Y,Tse W,Bunting KD. Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5. PLoS One 2010; 5: e9152.
  • 20
    Gu H,Pratt JC,Burakoff SJ,Neel BG. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell 1998; 2: 729740.
  • 21
    Nishida K,Yoshida Y,Itoh M,Fukada T,Ohtani T,Shirogane T,Atsumi T,Takahashi-Tezuka M,Ishihara K,Hibi, M,Hirano, T. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 1999; 93: 18091816.
  • 22
    Kent DG,Dykstra BJ,Cheyne J,Ma E,Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood 2008; 112: 560567.
  • 23
    Audet J,Miller CL,Rose-John S,Piret JM,Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc Natl Acad Sci USA 2001; 98: 17471762.
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    Mangi MH,Newland AC. Interleukin-3 in hematology and oncology: Current state of knowledge and future directions. Cytokines Cell Mol Ther 1999; 5: 8795.
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    Nie Y,Han Y,Zou Y. CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med 2008; 205: 777783.
  • 26
    Lazarus HM,Lazarus HM,Sommers SR,Arfons LM,Fu P,Ataergin SA,Kaye NM,Liu F,Kindwall-Keller TL,Cooper BW,Laughlin MJ,Creger RJ,Barr PM,Gerson SL,Kaplan D. Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: Flow cytometric analysis of hematopoietic progenitor cell grafts. Biol Blood Marrow Transplant 2011; 17: 970978.
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    Meyerson HJ,MacLennan G,Husel W,Tse W,Lazarus HM,Kaplan D. D cyclins in CD5+ B-cell lymphocproliferative disorders. Cyclin D1 and cyclin D2 identify diagnostic groups and cyclin D1 correlates with ZAP-70 expression in chronic lymphocytic leukemia. Am J Clin Pathol 2006; 125: 241250.
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    Kaplan D. Current protocols in cytometry. In: Robinson JP, editor. New York, NY: Wiley; 2003. 6.14.16.14.11.
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    Kaplan D,Meyerson H,Husel W,Lewandowska K,MacLennan G. D cyclins in lymphocytes. Cytometry A 2005; 63A: 19.
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    Kaplan D,Smith D,Meyerson H,Pecora N,Lewandowska, K. CD5 expression by B lymphocytes and its regulation upon Epstein-Barr Virus transformation. Proc Natl Acad Sci USA 2001; 98: 1385013853.
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    Kaplan D,Meyerson HJ,Li X,Drasny C,Liu F,Costaldi M,Barr P,Lazarus HM Correlation between ZAP-70, phospho-ZAP-70, and phospho-Syk expression in leukemic cells from patients with CLL. Cytometry B 2010; 78B: 115122.
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    Kaplan D,Smith D. Enzymatic amplification staining for flow cytometric analysis of cell surface molecules. Cytometry 2000; 40: 8185.
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    Kadereit S,Deeds LS,Haynesworth SE,Koc ON,Kozik MM,Szekely E,Daum-Woods K,Goetchius GW,Fu P,Welniak LA,Murphy WJ,Laughlin MJ. Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(−) early progenitors cultured over human MSCs as a feeder layer. Stem Cells 2002; 20: 573582.
  • 34
    Majeti R,Park CY,Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 2007; 1: 635645.
  • 35
    Doulatov S,Notta F,Eppert K,Nguyen LT,Ohashi PS,Dick JE. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol 2010; 11: 585593.
  • 36
    Schiedlmeier B,Santos AC,Riberio A,Moncaut N,Lesinshi D,Auer H,Kornacker K,Ostertag W,Baum C,Mallo M,Klump H. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci USA 2007; 104: 1695216957.
  • 37
    Haddad R,Pflumio F,Vigon I,Visentin G,Auvray C,Fichleson S,Amsellem S. The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors. Stem Cells 2008; 26: 312322.
  • 38
    Tang Y,Chen J,Young NS. 2009. Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4. Br J Haemotol 2009; 144: 603612.
  • 39
    Watts KL,Delaney C,Humphries RK,Bernstein ID,Kiem H-P. Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells. Blood 2010; 116: 58595866.
  • 40
    Schiedlmeier B,Klump H,Will E,Arman-Kalcek G,Li Z,Wang Z,Rimek A,Friel J,Baum C,Ostertag W. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Blood 2003; 101: 17591768.
  • 41
    Pilat S,Carotta S,Schiedlmeier B,Kamino K,Mairhofer A,Will E,Modlich U,Steinlein P,Ostertag W,Baum C,Beug H,Klump H. HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells. Proc Natl Acad Sci USA 2005; 102: 1210112106.
  • 42
    Fukumoto S,Hsieh C,Maemura K,Layne MD,Yet S,Lee, K,Matsui T,Rosenzwieg A,Taylor WG,Rubin JS,Perrella MA,Lee M. Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 2001; 276: 1747917483.
  • 43
    Yamazaki S,Iwama A,Takayanagi S,Morita Y,Eto K,Ema H,Nakauchi H. Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J 2006; 25: 35153523.