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The elite and stochastic model for iPS cell generation: Multilineage-differentiating stress enduring (Muse) cells are readily reprogrammable into iPS cells

  1. Shohei Wakao1,
  2. Masaaki Kitada1,
  3. Mari Dezawa1,2,*

Article first published online: 12 JUN 2012

DOI: 10.1002/cyto.a.22069

Issue

Cytometry Part A

Cytometry Part A

Special Issue: Cytometry in Stem Cell Research

Volume 83A, Issue 1, pages 18–26, January 2013

Additional Information

How to Cite

Wakao, S., Kitada, M. and Dezawa, M. (2013), The elite and stochastic model for iPS cell generation: Multilineage-differentiating stress enduring (Muse) cells are readily reprogrammable into iPS cells. Cytometry, 83A: 18–26. doi: 10.1002/cyto.a.22069

Author Information

  1. 1

    Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan

  2. 2

    Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan

*Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan

Publication History

  1. Issue published online: 19 DEC 2012
  2. Article first published online: 12 JUN 2012
  3. Manuscript Accepted: 16 APR 2012
  4. Manuscript Revised: 2 APR 2012
  5. Manuscript Received: 24 FEB 2012

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Keywords:

  • mesenchymal stem cells;
  • elite model;
  • iPS cells;
  • adult stem cells

Abstract

Induced pluripotent stem (iPS) cells have attracted a great deal of attention, although the mechanism by which they are generated is still not fully understood. Currently, two theories, the stochastic and elite models, have been proposed. Some reports provide theoretical support for the stochastic model. Other reports, however, support the elite model. For example, some human fibroblasts, such as Multilineage-differentiating stress enduring (Muse) cells, are reported to be pluripotent and a primary source of iPS cells. Thus, the mechanism of iPS cell generation continues to be debated. In this review, we discuss the properties of the original cell source, such as the components of the original populations and the potential of each population to become iPS cells, and further discuss the implications of the two theories for iPS cell research. © 2012 International Society for Advancement of Cytometry

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