CD4 T cell subsets and tuberculosis infection
Tuberculosis remains a critically important public health problem, with almost one third of the world's population impacted by it, primarily in Africa, throughout Asia and North-Western South America. The usual triad of drug resistance, poverty, and HIV infection combine to maintain this disease as a potent enemy of human health. As issues of host immunity are directly related to sensitivity to the disease, the case for integrating the study of tuberculosis infection with flow cytometric techniques has been made in this and other journals. Streitz and coworkers studied the relationship between CD4+ T cell subsets and the control of tuberculosis, finding the existence of functional subset disparity between the stages of disease and active versus inactive infections.
Streitz et al., Cytometry B Clin Cytom 2012; 82B:360–368.