Seeing double trouble
One of the most common uses of flow cytometry in the clinical laboratory is for the detection of leukemic cells in the bone marrow or peripheral circulation. While clinicians most often suspect a single lineage of leukemic cells, it is not altogether uncommon for the cytometry results to reveal a bilineal, or mixed ?phenotypic acute leukemia (MPAL). ?Rahman and colleagues report an unusual case of a patient presenting with both T and B lineages among the leukemic blasts. Even among MPAL this phenotype is rare, with most cases displaying a myeloid component in addition to the lymphocytic lineage. Those who find the current case report of interest might also want to review a previous case report in which three simultaneous lymphoproliferative disorders (HCL, B–CLL, and TLGL) were detected in both peripheral blood and bone marrow.
Rahman et al., Cytometry Part B 2013; 84B:198–201.
Contributor: J. Philip McCoy Jr., Ph.D., Bethesda, MD.