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On the cover: The cover reveals images of γH2AX foci (red) and DNA replication regions (green) at different points in the cell cycle S-phase. Mechanistic insights related to the role of oxidative stress and induction are described using the authors' method of quantitative analysis of spatial relationships between individually distinct nuclear events. See the accompanying article by Berniak and colleagues in this issue.

Cover design by Bärbel Beran [www.beran-design.de].