• 1
    Fukada KE, Straus SE, Hickie L, Sharpe MC, Dobbins JG, Komaroff A, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121: 953959.
  • 2
    Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988; 108: 387389.
  • 3
    Komaroff AL. Clinical presentation of chronic fatigue syndrome [Ciba Foundation Symposium 173]. Chichester, UK: Wiley; 1993. p 4361.
  • 4
    Natelson BH, Haghighi M, Ponzio NM. Evidence for the presence of immune dysfunction in chronic fatigue syndrome. Clin Diagn Lab Immunol 2002; 747752.
  • 5
    Patarcha R, Mark T, Fletcher MA, Klimnas N. Immunology of chronic fatigue syndrome. J Chronic Fatigue Syndr 2000; 6: 69102.
  • 6
    Gupta S, Vayuvegula B. A comprehensive immunological analysis in chronic fatigue syndrome. Scand J Immunol 1991; 33: 319327.
  • 7
    Patarcha R. Cytokine and chronic fatigue syndrome. Ann N Y Acad 2001; 933: 185200.
  • 8
    Zhang Q, Zhou X, Denny T, Ottenweller JE, Lange G, LaManca JJ, Lavietes MH, Pollet C, Gause WC, Natelson BH. Changes in immune function parameters seen in Gulf War syndrome veterans but not in civilians with chronic fatigue syndrome. Clin Diagn Lab Immunol 1999; 6 (1): 613.
  • 9
    Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA. Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis 1994; 18 (Suppl 1): S136S141.
  • 10
    Hassan IS, Bannister BA, Akbar A, Weir W, Bifukk M. A study of the immunology of chronic fatigue syndrome: correlation of immunologic markers of health dysfunction. Clin Immunol Immunopathol 1998; 87: 6067.
  • 11
    Klimas NG, Salvato FR, Morgan R, Fletcher MA. Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 1990; 28: 14031410.
  • 12
    Landay AL, Jessop C, Lennette ET, Levy JA. CFS: clinical condition associated with immune activation. Lancet 1991; 338: 707712.
  • 13
    Caligiuri M, Murray C, Buchwald D, Levine H, Cheney P, Peterson D, Komaroff AL, Ritz J. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol 1987; 139: 33063313.
  • 14
    Levine PH, Dale JK, Benson-Gigg E, Fritz S, Grufferman S, Straus SE. A cluster of cases of chronic fatigue and chronic fatigue syndrome. Clin Infect Dis 1996; 23: 408409.
  • 15
    Musada A, Nozoe SL, Matsuyama T, Tanaka H. Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome. Psychosom Med 1994; 56: 512518.
  • 16
    Ojo-Amaize EA, Conley EJ, Peter JB. Decreased natural killer cell activity is associated with severity of chronic fatigue-immune dysfunction syndrome. Clin Infect Dis 1994; 18 (Suppl 1): S157S159.
  • 17
    See DM, Cimoch S, Chou J, Chang J, Tilles J. The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Integr Physiol Behav Sci 1998; 33: 280287.
  • 18
    Ablashi DV, Eastman HB, Owen CB, Roman NM, Friedman J, Zabriskie JB, Peterson DL, Pearson GR, Whitman JE. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J Clin Virol 2000; 16: 179191.
  • 19
    Buchwald D, Cheney PR, Peterson DL, Henry B, Wormsley SB, Geiger A, Ablashi DV, Salahuddin SZ, Saxinger C, Biddle R. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active herpes virus 6 infection. Ann Intern Med 1992; 116: 103113.
  • 20
    Glaser R, Kelcolt-Glaser JK. Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome. Am J Med 1998; 105: 35S43S.
  • 21
    Morag A, Tobi M, Ravid Z, Revel M, Schattner A. Increased (2′5′)-oligo-asynthetase activity in patients with prolonged illness associated with serological evidence of persistent Epstein-Barr virus infection. Lancet 1982; 1: 744.
  • 22
    Bergner M, Bobbitt RA, Carter W, Gilson BS. The sickness impact profile: development and final revision of a health status measure. Med Care 1981; 19: 787805.
  • 23
    Gilson BS, Gilson JS, Bergner M, Bobbitt RA, Kressel S, Pollard WE, Vesselagao M. The sickness impact profile: development of an outcome measure of health care. Am J Public Health 1975; 65: 13041310.
  • 24
    Stewart CC, Stewart SJ. Immunophenotyping. In: RobinsonJP, DarzynkiewiczZ, DeanP, DresslerL, RabinovitchP, StewartC, TankeH, WheelessL, editors. Current protocols in cytometry. New York: J. Wiley & Sons, 1997. p
  • 25
    Baxter AG, Smyth MJ. The role of NK cells in autoimmune disease. Autoimmunity 2002; 35: 114.
  • 26
    Yamamura T. Therapeutic strategy for multiple sclerosis targeting NK and NKT cells. Rinsho Shineigaku 2001; 41: 11621164.
  • 27
    Yanagihara Y, Shiozawa K, Takai M, Kyogoku M, Shiozawa S. Natural killer (NK) cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis. Clin Exp Immunol 1999; 118: 131136.
  • 28
    Buchwald D, Herrell R, Ashton S, Belcourt M, Schmaling K, Sullivan P, Neale M, Goldberg J. A twin study of chronic fatigue. Psychosom Med 2001; 63: 936943.
  • 29
    Hickie IB, Bansai AS, Kirk KM, Loyd AR, Martin NG. A twin study of the etiology of prolonged fatigue and immune activation. Twin Res 2001; 4: 94102.
  • 30
    Gunn WJ, Connell DB, Randall B. Chronic fatigue syndrome: epidemiology of chronic fatigue syndrome: the Centers for Disease Control Study [Ciba Foundation Symposium 173]. Chichester, UK: Wiley; 1993. p 83101.
  • 31
    Bell KM, Cookfair DL, Bell DS, Reese P, Cooper L. Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases. Rev Infect Dis 1991; 13 (Suppl 1): S32S38.
  • 32
    Nanan R, Rauch A, Kampgen E, Niewiesk S, Kreth HW. A novel approach for frequency analysis of measles virus-specific memory T-cell lymphocytes in healthy adults with childhood history of natural measles. J Gen Virol 2000; 81: 13131319.
  • 33
    Morrison LJA, Behan WHM, Behan PO. Changes in natural killer cell phenotype in patients with post-viral fatigue syndrome. Clin Exp Immunol 1991; 83: 441446.
  • 34
    Lanier LL, My Le A, Civin CI, Loken MR, Phillips JH. The relationship of CD16 (LEU-11) and LEU-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 1986; 136: 44804485.
  • 35
    Grufferman S, Levine PH, Eby NL, Muldoon SB, Huang MS, Whiteside TL, Penkower L, Herberman RB. Results of an investigation of three clusters of chronic fatigue syndrome. Clin Infect Dis 1994; 18: s55s56.