Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?
Version of Record online: 20 AUG 2004
Copyright © 2004 John Wiley & Sons, Ltd.
Depression and Anxiety
Volume 20, Issue 2, pages 98–100, 2004
How to Cite
Li, X., Nahas, Z., Anderson, B., Kozel, F. A. and George, M. S. (2004), Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?. Depress. Anxiety, 20: 98–100. doi: 10.1002/da.20027
- Issue online: 4 OCT 2004
- Version of Record online: 20 AUG 2004
- Manuscript Accepted: 5 JUN 2004
- Manuscript Revised: 10 JAN 2004
- Manuscript Received: 1 JUL 2003
- Stanley Foundation
- Neotonus, Inc.
Numerous studies have examined the acute antidepressant effects of prefrontal transcranial magnetic stimulation (TMS). However, there is little information on whether TMS can be used as a maintenance treatment to maintain normal mood once subjects have responded. We describe seven adults with bipolar depression who responded acutely to TMS and were then treated with TMS weekly for up to 1 year. TMS was carried out over the left prefrontal cortex at 110% motor threshold, 5 Hz for 8 s for 40 trains. Three subjects completed 1 full year of weekly TMS with an average Hamilton Rating Scale for Depression of 13 (sd=5.9) over the year. These data suggest but do not prove that TMS might eventually be used as an adjunctive maintenance treatment for at least some patients with bipolar depression. Much work remains. Depression and Anxiety 00:000–000, 2004. © 2004 Wiley-Liss, Inc.