This article is a US Government and, as such, is in the public domain of the United States of America.
In search of mixed anxiety–depressive disorder: a primary care study†
Article first published online: 1 MAR 2006
This article is a U.S. Government work and is in the public domain in the U.S.A. Published in 2006 by Wiley-Liss, Inc.
Depression and Anxiety
Volume 23, Issue 4, pages 183–189, 2006
How to Cite
Means-Christensen, A. J., Sherbourne, C. D., Roy-Byrne, P. P., Schulman, M. C., Wu, J., Dugdale, D. C., Lessler, D. and Stein, M. B. (2006), In search of mixed anxiety–depressive disorder: a primary care study. Depress. Anxiety, 23: 183–189. doi: 10.1002/da.20164
- Issue published online: 19 JUN 2006
- Article first published online: 1 MAR 2006
- Manuscript Accepted: 9 DEC 2005
- Manuscript Revised: 11 OCT 2005
- Manuscript Received: 20 JUL 2004
- National Institutes of Health. Grant Numbers: MH57858, MH065324 (to P. Roy-Byrne), MH57835, MH64122 (to M. Stein)
- Eli Lilly and Company (unrestricted research grant)
- mixed anxiety–depressive disorder;
- primary care
The diagnosis of mixed anxiety–depressive disorder, as proposed in DSM-IV, is intended to be useful in settings such as primary care, where low-level anxiety and depressive symptoms may cause clinically significant impairment but are undiagnosable using current criteria. Evidence of the prevalence of this diagnosis is, however, lacking, particularly since the publication of the proposed diagnostic criteria in DSM-IV. Our study examined symptoms of anxiety and depression in 65 primary care patients screened for anxiety and depression while visiting their doctor. Results indicated that of the 37 patients without a diagnosable anxiety or depressive disorder, none had symptoms of depression and anxiety accompanied by interference that the patient deemed significant and attributable to his or her symptoms. These data dispute the need for a mixed anxiety–depression category (beyond mood and anxiety syndromes currently in DSM-IV) in future editions of the DSM. Depression and Anxiety 23:183–189, 2006. Published 2006 Wiley-Liss, Inc.