This article is a US government work and, as such, is in the public domain in the United States of America.
Factor analysis of the Yale–Brown Obsessive Compulsive Scale in a family study of obsessive–compulsive disorder†
Version of Record online: 4 AUG 2006
This article is a U.S. Government work and is in the public domain in the U.S.A. Published in 2006 by John Wiley & Sons, Ltd.
Depression and Anxiety
Volume 24, Issue 2, pages 130–138, 2007
How to Cite
Cullen, B., Brown, C. H., Riddle, M. A., Grados, M., Bienvenu, O. J., Hoehn-Saric, R., Shugart, Y. Y., Liang, K.-Y., Samuels, J. and Nestadt, G. (2007), Factor analysis of the Yale–Brown Obsessive Compulsive Scale in a family study of obsessive–compulsive disorder. Depress. Anxiety, 24: 130–138. doi: 10.1002/da.20204
- Issue online: 23 JAN 2007
- Version of Record online: 4 AUG 2006
- Manuscript Accepted: 11 FEB 2006
- Manuscript Revised: 8 FEB 2006
- Manuscript Received: 6 OCT 2005
- National Institutes of Health, Division of Research Resources, General Clinical Research Centers. Grant Number: R01 MH 50214
Our objective in this study was to determine whether symptoms of obsessive–compulsive disorder (OCD) cluster into groups that can usefully subclassify OCD. Psychiatrists or psychologists interviewed 221 subjects using the Lifetime Anxiety Version of the Schedule for Affective Disorders and Schizophrenia (SADS-LA) for the diagnosis of DSM-IV disorders, and the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) for OCD symptoms. We analyzed 16 symptom categories from the Y-BOCS using exploratory factor analysis to identify latent symptom dimensions. The relationship between these symptom dimensions and clinical characteristics and familiality was investigated. A four-factor model emerged as the best classification of OCD symptoms in the Y-BOCS. These factors were labeled Pure Obsessions, Contamination, Symmetry/Order, and Hoarding. The contamination factor was least likely to be associated with other Axis I disorders. Whereas no significant relationship was found between the factor scores of probands and the presence of OCD in their first-degree relatives, the Symmetry/Order and Hoarding factors did breed true. Hoarding was found to predict poorer treatment response. A four-factor classification of OCD features best describes the symptom patterns of a sample of patients with OCD. There were specific clinical correlates for these factors, and significant intrafamilial sib–sib correlations were found for the Symmetry/Order and Hoarding factors. Anxiety and Depression 24:130–138, 2007. Published 2006 Wiley-Liss, Inc.