This article is a US Government work and, as such, is in the public domain in the United States of America.
Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder†
Article first published online: 12 MAR 2007
This article is a U.S. Government work and is in the public domain in the U.S.A. Published in 2007 by Wiley-Liss, Inc.
Depression and Anxiety
Volume 25, Issue 3, pages 260–271, March 2008
How to Cite
Strawn, J. R. and Geracioti, T. D. (2008), Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress. Anxiety, 25: 260–271. doi: 10.1002/da.20292
- Issue published online: 25 MAR 2008
- Article first published online: 12 MAR 2007
- Manuscript Accepted: 5 OCT 2006
- Manuscript Revised: 4 OCT 2006
- Manuscript Received: 22 JUN 2006
- posttraumatic stress disorder;
- anxiety disorders;
- cerebrospinal fluid;
- central nervous system
The catecholamine norepinephrine is a critical effector of the mammalian stress response and has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD)—a syndrome intrinsically related to the experience of extraordinary stress. Symptom-linked hypernoradrenergic derangements have been observed in PTSD and several studies have examined the potential therapeutic effects of agents that dampen the centrally hyperactive noradrenergic state. These agents include compounds that decrease norepinephrine release (e.g. centrally acting α2 agonists such as clonidine) and those which block post-synaptic norepinephrine receptors (e.g. centrally acting α1 or β receptor antagonists such as prazosin or propranolol). In this article, we review studies of central noreadrenergic hyperactivity under both basal and challenge conditions and explore the evidence for these derangements as potential psychopharmacologic targets in patients with PTSD. Given the significant involvement of CNS norepinephrine hyperactivity in PTSD, and its link to intrusive and hyperarousal symptoms, it is not surprising that interventions directed at this system have therapeutic potential in PTSD. The utility of these anti-adrenergics in the clinical treatment of PTSD remains to be determined, though it is possible that they may prove to have primary roles in a disorder that is only modestly responsive to antidepressant treatment. Depression and Anxiety 0:1–12, 2007. Published 2007 Wiley-Liss, Inc.