A population-based family study of minor depression
Article first published online: 15 MAR 2009
© 2009 Wiley-Liss, Inc.
Depression and Anxiety
Volume 26, Issue 4, pages 389–392, April 2009
How to Cite
Newman, S. C. and Bland, R. C. (2009), A population-based family study of minor depression. Depress. Anxiety, 26: 389–392. doi: 10.1002/da.20560
- Issue published online: 30 MAR 2009
- Article first published online: 15 MAR 2009
- Manuscript Accepted: 10 FEB 2009
- Manuscript Revised: 4 FEB 2009
- Manuscript Received: 18 NOV 2008
- minor depression;
- familial aggregation;
Background: There is a paucity of research on whether minor depression is a familial disorder. Methods: We conducted a population-based family study of minor depression in which subjects were interviewed using the Diagnostic Interview Schedule (DIS). Minor depression only (MDO) was diagnosed if there was a lifetime history of what the DIS refers to as a depressive “spell” and no lifetime history of either Diagnostic and Statistical Manual of Mental Disorders, Third Edition, major depression or dysthymia. There were 71 probands with a lifetime history of MDO; 577 controls with no lifetime history of MDO, major depression, or dysthymia; and 1,539 first-degree relatives (FDRs). Logistic regression was performed with the presence/absence of MDO in a proband/control as the “exposure” and MDO in an FDR as the “outcome”. Results: The odds ratio for the association between MDO in a proband and MDO in an FDR, after adjusting for age and sex of the FDR, was 1.55 (95% confidence interval: 0.93–2.58; P=.093). The study had 80% power to detect an odds ratio as small as 1.97, which is in the range of odds ratios seen for the familial aggregation of major depression. Conclusions: MDO does not appear to be a familial disorder, raising questions about the validity of “minor depression” as a distinct psychiatric syndrome. Depression and Anxiety, 2009. © 2009 Wiley-Liss, Inc.