Tanja Jovanovic and Nineequa Blanding contributed equally.
Childhood abuse is associated with increased startle reactivity in adulthood†
Version of Record online: 18 AUG 2009
This is a US Government work and, as such, is in the public domain in the United States of America. Published 2009 Wiley-Liss, Inc.
Depression and Anxiety
Volume 26, Issue 11, pages 1018–1026, November 2009
How to Cite
Jovanovic, T., Blanding, N. Q., Norrholm, S. D., Duncan, E., Bradley, B. and Ressler, K. J. (2009), Childhood abuse is associated with increased startle reactivity in adulthood. Depress. Anxiety, 26: 1018–1026. doi: 10.1002/da.20599
This is a US Government work and, as such, in the public domain in the United States of America.
- Issue online: 2 NOV 2009
- Version of Record online: 18 AUG 2009
- Manuscript Accepted: 7 JUL 2009
- Manuscript Revised: 1 JUL 2009
- Manuscript Received: 22 MAY 2009
- National Institutes of Mental Health. Grant Number: MH071537
- Emory and Grady Memorial Hospital General Clinical Research Center; NIH National Centers for Research Resources. Grant Number: M01 RR00039
- Burroughs Wellcome Fund
- child abuse;
- childhood maltreatment;
Background: Understanding the neurobiological correlates of childhood maltreatment is critical to delineating stress-related psychopathology. The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress. Methods: We measured ASR to a 40 ms noise probe as well as fear-potentiated startle using electromyographic recordings of the eyeblink in a primarily African American sample (N=60) from a highly traumatized civilian population. We assessed self-reported history of abuse with the Childhood Trauma Questionnaire and current symptoms with the PTSD Symptom Scale and the Beck Depression Inventory. Results: We found that subjects reporting a history of high levels of physical or sexual abuse had increased startle on all trial types relative to those with low abuse (P<.01). This effect remained significant after co-varying for the subjects' age and sex, as well as PTSD and depression symptoms. Perceived childhood sexual abuse was the greatest predictor of increased startle response. Notably, emotional abuse in childhood did not affect baseline startle, and all groups demonstrated equivalent levels of fear-potentiated startle. Conclusions: The long-lasting effects of early life trauma result in increased risk for adult psychopathology. These new data demonstrate that a self-report history of child abuse is related to altered baseline startle response that is not accounted for by PTSD or depression symptoms. Increased startle may be a biomarker of stress responsiveness that can be a persevering consequence of early trauma exposure during childhood. Depression and Anxiety 26:1018–1026, 2009. Published 2009 Wiley-Liss, Inc.