The authors report they have no financial relationships within the past 3 years to disclose.
Separation anxiety disorder in OCD†
Article first published online: 9 FEB 2011
© 2011 Wiley-Liss, Inc.
Depression and Anxiety
Volume 28, Issue 3, pages 256–262, March 2011
How to Cite
Mroczkowski, M. M., Goes, F. S., Riddle, M. A., Grados, M. A., Joseph Bienvenu, O., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Knowles, J. A., Piacentini, J., Cullen, B., Rasmussen, S. A., Geller, D. A., Pauls, D. L., Liang, K.-Y., Nestadt, G. and Samuels, J. F. (2011), Separation anxiety disorder in OCD. Depress. Anxiety, 28: 256–262. doi: 10.1002/da.20773
- Issue published online: 10 MAR 2011
- Article first published online: 9 FEB 2011
- Manuscript Accepted: 30 OCT 2010
- Manuscript Revised: 26 OCT 2010
- Manuscript Received: 11 AUG 2010
- obsessive–compulsive disorder;
- separation anxiety disorder;
- personality disorders
Background: A history of separation anxiety disorder (SAD) is frequently reported by patients with obsessive–compulsive disorder (OCD). The purpose of this study was to determine if there are clinical differences between OCD-affected individuals with, versus without, a history of SAD. Methods: Using data collected during the OCD Collaborative Genetic Study, we studied 470 adult OCD participants; 80 had a history of SAD, whereas 390 did not. These two groups were compared as to onset and severity of OCD, lifetime prevalence of Axis I disorders, and number of personality disorder traits. Results: OCD participants with a history of SAD were significantly younger than the non-SAD group (mean, 34.2 versus 42.2 years; P<.001). They had an earlier age of onset of OCD symptoms (mean, 8.0 versus 10.5 years; P<.003) and more severe OCD, as measured by the Yale–Brown Obsessive Compulsive Scale (mean, 27.5 versus 25.0; P<.005). In addition, those with a history of SAD had a significantly greater lifetime prevalence of agoraphobia (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.4–4.6, P<.003), panic disorder (OR = 1.84, CI = 1.03–3.3 P<.04), social phobia (OR = 1.69, CI 1.01–2.8, P<.048), after adjusting for age at interview, age at onset of OCD, and OCD severity in logistic regression models. There was a strong relationship between the number of dependent personality disorder traits and SAD (adjusted OR = 1.42, CI = 1.2–1.6, P<.001). Conclusions: A history of SAD is associated with anxiety disorders and dependent personality disorder traits in individuals with OCD. Depression and Anxiety 28:256–262, 2011. © 2011 Wiley-Liss, Inc.