No conflict of interest was declared.
Stressful life events at onset of obsessive–compulsive disorder are associated with a distinct clinical pattern†
Version of Record online: 9 FEB 2011
© 2011 Wiley-Liss, Inc.
Depression and Anxiety
Volume 28, Issue 5, pages 367–376, May 2011
How to Cite
Real, E., Labad, J., Alonso, P., Segalàs, C., Jiménez-Murcia, S., Bueno, B., Subirà, M., Vallejo, J. and Menchón, J. M. (2011), Stressful life events at onset of obsessive–compulsive disorder are associated with a distinct clinical pattern. Depress. Anxiety, 28: 367–376. doi: 10.1002/da.20792
- Issue online: 29 APR 2011
- Version of Record online: 9 FEB 2011
- Manuscript Accepted: 22 DEC 2010
- Manuscript Revised: 14 DEC 2010
- Manuscript Received: 3 AUG 2010
- Spanish Ministry of Health
- Instituto de Salud Carlos III
- Fondo de Investigaciones Sanitarias de la Seguridad Social. Grant Numbers: PI071029, PI071044, CIBER-CB06/03/0034
- Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)
- stressful life events;
- obsessive–compulsive disorder;
- environmental stressors;
- symptom dimensions;
- complicated birth
Background: Environmental stressors are considered to play an important role in the triggering of mental disorders such as obsessive–compulsive disorder (OCD). Although there is extensive literature on traumatic life events, little is known about the role of nontraumatic but nonetheless stressful life events (SLEs) in OCD. The aim of this study was to establish whether OCD preceded by an SLE presents a different clinical pattern compared to non-SLE-preceded OCD. Methods: We interviewed 412 OCD patients to assess both SLEs at onset of OCD and other clinical variables, including OCD symptom dimensions. Logistic regression was then applied to explore the relationship between clinical variables and OCD preceded by an SLE. Results: The SLE-preceded OCD group showed a later onset of the disorder (OR = 1.04, P = .015), a history of complicated birth (OR = 5.54, P<.001), less family history of OCD (OR = 0.42, P = .014), and the presence of contamination/cleaning symptoms (OR = 1.99, P = .01). Conclusions: Patients with OCD onset close to an SLE and those without an SLE close to OCD onset show a distinct clinical pattern. Depression and Anxiety, 2011. © 2011 Wiley-Liss, Inc.