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PSYCHOSOCIAL FEATURES ASSOCIATED WITH LIFETIME COMORBIDITY OF MAJOR DEPRESSION AND ANXIETY DISORDERS AMONG A COMMUNITY SAMPLE OF MID-LIFE WOMEN: THE SWAN MENTAL HEALTH STUDY

Authors

  • Jill M. Cyranowski Ph.D.,

    Corresponding author
    1. Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania
    • Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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  • Laura L. Schott Ph.D.,

    1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • Howard M. Kravitz D.O., M.P.H.,

    1. Departments of Psychiatry and Preventive Medicine, Rush University Medical Center, Chicago, Illinois
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  • Charlotte Brown Ph.D.,

    1. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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  • Rebecca C. Thurston Ph.D.,

    1. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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  • Hadine Joffe M.D., M.Sc.,

    1. Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts
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  • Karen A. Matthews Ph.D.,

    1. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    2. Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania
    3. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • Joyce T. Bromberger Ph.D.

    1. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    2. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
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Correspondence to: Jill M. Cyranowski, Western Psychiatriatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213. E-mail: cyranowskijm@upmc.edu

Abstract

Background

In clinical samples, comorbidity between depressive and anxiety disorders is associated with greater symptom severity and elevated suicide risk. Less is known, however, regarding the long-term psychosocial impact that a lifetime history of both major depressive disorder (MDD) and one or more anxiety disorders has in community samples. This report evaluates clinical, psychological, social, and stress-related characteristics associated with a lifetime history of MDD and anxiety.

Methods

Data from 915 women aged 42–52 who were recruited as part of the the Study of Women's Health across the Nation (SWAN) Mental Health Study were used to examine clinical and psychosocial features across groups of women with a lifetime history of MDD alone, anxiety alone, both MDD and anxiety, or neither MDD nor anxiety.

Results

As compared with women with a history of either MDD or anxiety alone, women with a comorbid history were more likely to report recurrent MDD, multiple and more severe lifetime anxiety disorders, greater depressive and anxiety symptoms, diminished social support, and more past-year distressing life events. Exploratory analyses indicated that women with a comorbid history also report more childhood abuse/neglect and diminished self-esteem, as compared with women with a history of either disorder alone.

Conclusions

Midlife women with a comorbid history that includes both MDD and anxiety disorders report diminished social support, more symptomatic distress, and a more severe and recurrent psychiatric history. Future research is needed to clarify the biological and psychosocial risk factors associated with this comorobid profile, and to develop targeted interventions for this at-risk group. Depression and Anxiety 00:1-8, 2012. © 2012 Wiley Periodicals, Inc.

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