THE EFFICACY OF A TOPICAL SIALOGOGUE SPRAY CONTAINING 1% MALIC ACID IN PATIENTS WITH ANTIDEPRESSANT-INDUCED DRY MOUTH: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL
Version of Record online: 1 NOV 2012
© 2012 Wiley Periodicals, Inc.
Depression and Anxiety
Volume 30, Issue 2, pages 137–142, February 2013
How to Cite
Gómez-Moreno, G., Aguilar-Salvatierra, A., Guardia, J., Uribe-Marioni, A., Cabrera-Ayala, M., Delgado-Ruiz, R. A. and Calvo-Guirado, J. L. (2013), THE EFFICACY OF A TOPICAL SIALOGOGUE SPRAY CONTAINING 1% MALIC ACID IN PATIENTS WITH ANTIDEPRESSANT-INDUCED DRY MOUTH: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL. Depress. Anxiety, 30: 137–142. doi: 10.1002/da.22017
- Issue online: 25 JAN 2013
- Version of Record online: 1 NOV 2012
- Manuscript Accepted: 8 OCT 2012
- Manuscript Revised: 1 OCT 2012
- Manuscript Received: 14 AUG 2012
- Proyecto de Investigación FIS. Grant Number: PI10/00932
- Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (Spain)
- Proyecto OTRI CNT-2856
- University of Granada-Dentaid S.L. (Barcelona, Spain)
- Regional Government of Andalucía (Spain)
- antidepressant drugs;
- dry mouth;
- malic acid
One of the most important antidepressants side effects is dry mouth. The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by dry mouth caused by antidepressants drug.
Materials and methods
This research took the form of a double-blind, randomized clinical trial at Faculty of Dentistry of University of Granada (Spain). Seventy participants with antidepressant-induced dry mouth were divided into two groups: for the first “intervention group” (35 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second “control group” (35 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Dry Mouth Questionnaire (DMQ) was used to evaluate dry mouth symptoms before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured.
Dry mouth symptoms improved after 1% malic acid topical spray application (p < .05). After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < .05).
A sialogogue spray containing 1% malic acid improved dry mouth feeling of the patients suffering antidepressant-induced dry mouth and increased unstimulated and stimulated salivary flows rates.