HIGHER IN VIVO SEROTONIN-1A BINDING IN POSTTRAUMATIC STRESS DISORDER: A PET STUDY WITH [11C]WAY-100635
Article first published online: 13 FEB 2013
© 2013 Wiley Periodicals, Inc.
Depression and Anxiety
Volume 30, Issue 3, pages 197–206, March 2013
How to Cite
Sullivan, G. M., Ogden, R. T., Huang, Y.-y., Oquendo, M. A., Mann, J. J. and Parsey, R. V. (2013), HIGHER IN VIVO SEROTONIN-1A BINDING IN POSTTRAUMATIC STRESS DISORDER: A PET STUDY WITH [11C]WAY-100635. Depress. Anxiety, 30: 197–206. doi: 10.1002/da.22019
- Issue published online: 6 MAR 2013
- Article first published online: 13 FEB 2013
- Manuscript Accepted: 6 OCT 2012
- Manuscript Revised: 26 SEP 2012
- Manuscript Received: 18 APR 2012
- American Foundation for Suicide Prevention (AFSP)
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- United States Public Health Service. Grant Numbers: MH62185, K08-MH67015
- posttraumatic stress disorder (PTSD);
- serotonin-1A (5-HT1A);
- positron emission tomography;
- major depressive disorder
Brain serotonin-1A receptors (5-HT1A) are implicated in anxiety. We compared regional brain 5-HT1A binding in medication-free participants with posttraumatic stress disorder (PTSD) and healthy volunteers using fully quantitative positron emission tomography (PET) methods.
Twenty patients with DSM-IV PTSD (13 with comorbid major depressive disorder, [MDD]) and 49 healthy volunteers underwent PET imaging with 5-HT1A antagonist radioligand [C-11]WAY100635. Arterial blood sampling provided a metabolite-corrected input function and the concentration of free ligand in plasma (fP) for estimation of regional binding potential, BPF ( = Bavailable / KD). Linear mixed modeling compared BPF between groups across regions of interest (ROIs).
The PTSD group had higher 5-HT1A BPF across brain ROIs (P = .0006). Post hoc comparisons showed higher 5-HT1A BPF in PTSD in all cortical ROIs (26–33%), amygdala (34%), and brainstem raphe nuclei (43%), but not hippocampus. The subgroup of seven PTSD patients without comorbid MDD had higher 5-HT1A BPF compared with healthy volunteers (P = .03).
This is the first report of higher brainstem and forebrain 5-HT1A binding in vivo in PTSD. The finding is independent of MDD. PTSD and MDD have in common an upregulation of 5-HT1A binding including midbrain autoreceptors that would favor less firing and serotonin release. This abnormality may represent a common biomarker of these stress-associated brain disorders.