INCREASED ERROR-RELATED BRAIN ACTIVITY IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER AND UNAFFECTED SIBLINGS
Version of Record online: 5 DEC 2012
© 2012 Wiley Periodicals, Inc.
Depression and Anxiety
Volume 30, Issue 1, pages 39–46, January 2013
How to Cite
Carrasco, M., Harbin, S. M., Nienhuis, J. K., Fitzgerald, K. D., Gehring, W. J. and Hanna, G. L. (2013), INCREASED ERROR-RELATED BRAIN ACTIVITY IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER AND UNAFFECTED SIBLINGS. Depress. Anxiety, 30: 39–46. doi: 10.1002/da.22035
- Issue online: 8 JAN 2013
- Version of Record online: 5 DEC 2012
- Manuscript Accepted: 9 NOV 2012
- Manuscript Revised: 29 OCT 2012
- Manuscript Received: 18 MAY 2012
- National Institute of Mental Health. Grant Numbers: R01 MH086321, F31 MH086273, K23 MH082176
- International OCD Foundation
- Dana Foundation
- National Alliance for Research on Schizophrenia and Depression Young Investigator Award
- anxiety disorder;
- error-related negativity;
- response monitoring;
- flanker task;
- medial frontal cortex;
The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential following an erroneous response and is thought to reflect ACC activity. This study was done to assess the ERN as a biomarker for OCD by comparing ERN amplitudes in pediatric OCD patients, unaffected siblings of pediatric OCD patients, and healthy controls.
The ERN and correct response negativity (CRN) were measured during an Eriksen flanker task to assess performance monitoring in 40 youth with a lifetime diagnosis of OCD, 19 unaffected siblings of OCD patients, and 40 unrelated healthy comparison subjects ranging in age from 10 to 17 years. ERN and CRN amplitudes were compared between groups using linear regression by the generalized estimating equation method to account for correlated data.
Compared to healthy controls, ERN amplitude was significantly increased in both pediatric OCD patients and unaffected siblings. There were no significant group differences in CRN amplitude. ERN amplitude in patients was unrelated to OCD symptom severity, current diagnostic status, or treatment effects.
Increased error-related brain potentials were observed not only in pediatric OCD patients but also in unaffected siblings. The results provide evidence that enhanced error-related brain activity may serve as a biomarker for OCD in youth that is independent of the presence of clinical symptoms. The ERN may be a useful quantitative phenotype in genetic studies of OCD.