Contract grant sponsor: American Foundation for Suicide Prevention (AFSP); University of Manitoba Graduate Fellowship and Manitoba Graduate Scholarship; Lundbeck Pharmaceuticals; Contract grant sponsor: Bristol-Myers Squibb; Contract grant sponsor: Canadian Institutes of Health Research New Investigator Award; Contract grant number: 113589.
FEAR OF DYING IN PANIC ATTACKS PREDICTS SUICIDE ATTEMPT IN COMORBID DEPRESSIVE ILLNESS: PROSPECTIVE EVIDENCE FROM THE NATIONAL EPIDEMIOLOGICAL SURVEY ON ALCOHOL AND RELATED CONDITIONS
Article first published online: 20 DEC 2012
© 2012 Wiley Periodicals, Inc.
Depression and Anxiety
Volume 30, Issue 10, pages 930–939, October 2013
How to Cite
Yaseen, Z. S., Chartrand, H., Mojtabai, R., Bolton, J. and Galynker, I. I. (2013), FEAR OF DYING IN PANIC ATTACKS PREDICTS SUICIDE ATTEMPT IN COMORBID DEPRESSIVE ILLNESS: PROSPECTIVE EVIDENCE FROM THE NATIONAL EPIDEMIOLOGICAL SURVEY ON ALCOHOL AND RELATED CONDITIONS. Depress. Anxiety, 30: 930–939. doi: 10.1002/da.22039
- Issue published online: 7 OCT 2013
- Article first published online: 20 DEC 2012
- Manuscript Accepted: 14 NOV 2012
- Manuscript Revised: 7 NOV 2012
- Manuscript Received: 11 SEP 2012
- American Foundation for Suicide Prevention (AFSP); University of Manitoba Graduate Fellowship and Manitoba Graduate Scholarship; Lundbeck Pharmaceuticals
- Bristol-Myers Squibb
- Canadian Institutes of Health Research New Investigator Award. Grant Number: 113589
- positive feedback;
- separation distress;
As a group, comorbid anxiety disorders among depressed persons have consistently been found to increase risk of suicide attempt (SA). Growing evidence supports the link between panic attacks (PAs) and suicidality, but prospective evidence is limited and the nature of the linkage remains unclear. The positive-feedback model of suicide suggests that PAs eliciting catastrophic cognitions may drive SA.
To prospectively examine the relationship between PAs, panic symptoms and suicidality in individuals meeting DSM-IV criteria for past-year major depressive episodes in a large epidemiological study.
In data on 2,864 participants of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) wave 1 and 2 surveys with depressive disorders, the associations of PAs and panic symptoms with subsequent suicidal ideation (SI) and SAs were assessed using logistic regression.
Past-year PAs in wave 1 significantly increased odds for subsequent SI and attempt in the 3-year follow-up interval; however, in multivariate analyses, PAs were not a significant predictor, but PAs featuring fear of dying were. Further, among subjects with PAs, fear of dying during a PA increased the odds of subsequent SA sevenfold, even after controlling for comorbid disorders, demographic factors, and other PA symptoms.
PAs characterized by prominent morbid catastrophic cognitions may mediate the transition to SIs and SAs in subjects with depressive episodes. Presence of these symptoms in clinical settings may serve as a warning sign for future suicidality.