Contract grant sponsor: NARSAD Distinguished Investigator Award; Contract grant sponsor: AFSP Established Investigator Award; Contract grant sponsor: NARSAD Young Investigator.
DECREASED BRAINSTEM AND PUTAMEN SERT BINDING POTENTIAL IN DEPRESSED SUICIDE ATTEMPTERS USING [11C]-ZIENT PET IMAGING
Article first published online: 22 MAR 2013
© 2013 Wiley Periodicals, Inc.
Depression and Anxiety
Volume 30, Issue 10, pages 902–907, October 2013
How to Cite
Nye, J. A., Purselle, D., Plisson, C., Voll, R. J., Stehouwer, J. S., Votaw, J. R., Kilts, C. D., Goodman, M. M. and Nemeroff, C. B. (2013), DECREASED BRAINSTEM AND PUTAMEN SERT BINDING POTENTIAL IN DEPRESSED SUICIDE ATTEMPTERS USING [11C]-ZIENT PET IMAGING. Depress. Anxiety, 30: 902–907. doi: 10.1002/da.22049
- Issue published online: 7 OCT 2013
- Article first published online: 22 MAR 2013
- Manuscript Accepted: 2 DEC 2012
- Manuscript Revised: 28 NOV 2012
- Manuscript Received: 9 AUG 2012
- NARSAD Distinguished Investigator Award
- AFSP Established Investigator Award
- NARSAD Young Investigator
- brain imaging/neuroimaging;
- biological markers;
Deficits in serotonergic neurotransmission have been implicated in the pathogenesis of depression and suicidality. The present study utilized a novel positron-emission tomography (PET) ligand to quantitate and compare brain regional serotonin transporter (SERT) binding potential in depressed patients with a past history of suicide attempts to that of healthy comparison subjects.
We used [11C]-ZIENT PET to label SERT in the serotonergic cell body rich brainstem, and forebrain projection fields. Quantitative PET emission data from 21 adults (10 healthy controls and 11 drug-free patients with major depression) was used for group comparison. SERT binding potential (BPND) in eight MRI-based brain regions of interest (ROI) were compared in high-resolution PET images.
SERT binding potential was significantly decreased in the midbrain/pons (P = .029) and putamen (P = .04) of depressed patients with a past suicide attempt relative to comparison subjects. Forebrain SERT binding was also reduced in the patient sample, though these region effects did not survive a multiple comparison correction.
These results suggest that decreased availability of the brainstem and basal ganglia SERT represents a biomarker of depression and thus confirm and extend the role of dysregulation of brain serotonergic neurotransmission in the pathophysiology of depression and suicide.