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MAINTENANCE TREATMENT WITH QUETIAPINE WHEN COMBINED WITH EITHER LITHIUM OR DIVALPROEX IN BIPOLAR I DISORDER: ANALYSIS OF TWO LARGE RANDOMIZED, PLACEBO-CONTROLLED TRIALS

Authors

  • Trisha Suppes M.D., Ph.D.,

    Corresponding author
    1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California
    2. Bipolar and Depression Research Program, VA Palo Alto Health Care System, Palo Alto, California
    • Correspondence to: Trisha Suppes, Department of Psychiatry and Behavioral Sciences, VA Bipolar and Depression Research Program, VA Palo Alto Health Care System, Stanford University School of Medicine, 3801 Miranda Avenue (151T), Palo Alto, CA 94304. E-mail: tsuppes@stanford.edu

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  • Eduard Vieta M.D., Ph.D.,

    1. Clinical Institute of Neuroscience, Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain
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  • Urban Gustafsson Ph.D.,

    1. AstraZeneca R&D, Södertälje, Sweden
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  • Birgit Ekholm M.D., Ph.D.

    1. Department of Psychiatry, University of Umeå, Umeå, Sweden
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  • Contract grant sponsor: AstraZeneca.

Abstract

Background

To determine the efficacy and safety of quetiapine combined with lithium or divalproex for preventing mood events in patients with bipolar I disorder. In this pooled analysis of two similar long-term studies (D1447C00126 [NCT00107731] and D1447C00127 [NCT00081380]), lithium and divalproex treatment groups were analyzed separately.

Methods

Patients received open-label quetiapine (400–800 mg/d) plus lithium or divalproex to achieve ≥12 weeks of clinical stability before being randomized to double-blind combination treatment with quetiapine (400–800 mg/d) or placebo plus lithium or divalproex for up to 104 weeks. The primary endpoint was time to first mood event postrandomization following open stabilization.

Results

Of 3,414 patients in the stabilization phase, 1,326 were randomized. There were no differences in the risk of recurrence of mood, mania, or depression between quetiapine plus lithium or quetiapine plus divalproex. Among patients co-treated with placebo and lithium, the risk of recurrence of a mania event was significantly higher than among patients co-treated with placebo and divalproex. In patients with an index episode of mania, placebo plus lithium was associated with a significantly higher risk of recurrence of a mania event than placebo plus divalproex. Safety data were generally consistent with recognized safety profiles.

Conclusions

In patients with bipolar I disorder previously stabilized on quetiapine and lithium or divalproex, maintenance therapy with quetiapine significantly increased the time to recurrence of a mood event (mania or depression) versus placebo, regardless of whether it was combined with lithium or divalproex.

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