In this paper, we demonstrate an empirical analysis of the reliability of low-rate wireless u-healthcare monitoring applications. We have considered the performance analysis of the IEEE 802.15.4 low-rate wireless technologies for u-healthcare applications. For empirical measurement, we considered three scenarios in which the reliability features of the low-rate wireless u-healthcare monitoring applications have been measured: (i) distance between sensor nodes and base station; (ii) deployment of the number of sensor nodes in a network; and (iii) data transmission by different time intervals. The experimental results show that received data are used to calculate BER and analyze the performance according to the scenarios. The BER is affected when varying the distance between sensor node and base station, the number of nodes, and time interval. Copyright © 2011 John Wiley & Sons, Ltd.