The three-signal hypothesis of lymphocyte activation/targets for immunosuppression
Version of Record online: 12 JAN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Dialysis & Transplantation
Volume 40, Issue 1, pages 14–16, January 2011
How to Cite
Goral, S. (2011), The three-signal hypothesis of lymphocyte activation/targets for immunosuppression. Dial. Transplant., 40: 14–16. doi: 10.1002/dat.20527
- Issue online: 12 JAN 2011
- Version of Record online: 12 JAN 2011
Kidney transplantation is the preferred mode of renal replacement therapy for most patients with end-stage renal disease. Despite the increasing success of transplantation over the years, allograft rejection remains a major problem. Recently, there has been considerable improvement in understanding the role of the immune system in rejection. In the setting of transplantation, T cells have proved to be crucial players in the immune response, and their activation has been shown to be a very tightly regulated process involving numerous interactions of receptors including the T-cell receptor (TCR):CD3 complex, co-stimulatory receptors, and appropriate signaling molecules, resulting in production of cytokines as well as clonal expansion and differentiation of effector T lymphocytes. In this review, current knowledge of the mechanisms of lymphocyte activation as well as potential targets for various immunosuppressive agents are discussed.