Belatacept in renal transplantation
Article first published online: 12 JAN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Dialysis & Transplantation
Volume 40, Issue 1, pages 33–36, January 2011
How to Cite
Yost, S. E., Ranga, K. V. and Kaplan, B. (2011), Belatacept in renal transplantation. Dial. Transplant., 40: 33–36. doi: 10.1002/dat.20531
- Issue published online: 12 JAN 2011
- Article first published online: 12 JAN 2011
Belatacept is a novel agent that prevents CD28 signaling and inhibits T-cell activation by costimulation blockade. It was developed from abatacept (CTLA-4 Ig), the ﬁrst recombinant immunoglobulin fusion protein that contains extracellular portion of CTLA-4, and the Fc domain of IgG. Early studies have shown that belatacept recipients show comparable patient and graft survival, superior renal function and renal biopsy data compared with cyclo-sporine-treated patients. Newer biologic agents such as belatacept offer the promise of real change—due to their lack of mechanism-related toxic effects—and help monitor drug administration, thereby improving compliance. Belatacept is a potential option for maintenance biologic therapy without a calcineurin inhibitor, accompanied by excellent mid-term results with yet unknown long-term safety and efﬁcacy. The increased rate of TCMR and possibly central nervous system post-transplantation lymphoproliferative disorder are worrisome and need to be further elucidated.