Cost-effectiveness of liquid-based cytology with or without hybrid-capture II HPV test compared with conventional Pap smears: A study by the French society of clinical cytology
Article first published online: 20 OCT 2005
Copyright © 2005 Wiley-Liss, Inc.
Special Issue: 2005 Symposium Issue
Volume 33, Issue 5, pages 338–343, November 2005
How to Cite
Cochand-Priollet, B., Cartier, I., de Cremoux, P., Le Galès, C., Ziol, M., Molinié, V., Petitjean, A., Dosda, A., Merea, E., Biaggi, A., Gouget, I., Arkwright, S., Vacher-Lavenu, M.-C., Vielh, P. and Coste, J. (2005), Cost-effectiveness of liquid-based cytology with or without hybrid-capture II HPV test compared with conventional Pap smears: A study by the French society of clinical cytology. Diagn. Cytopathol., 33: 338–343. doi: 10.1002/dc.20283
- Issue published online: 20 OCT 2005
- Article first published online: 20 OCT 2005
- Manuscript Accepted: 25 MAR 2005
- Manuscript Received: 12 MAR 2004
- French Ministère des Affaires Sociales (Direction Générale de la Santé, Programme Hospitalier de Recherche Clinique. Grant Number: A0M 98010.1998
- Association de Recherche sur le Cancer. Grant Number: 9099.1999
- conventional Pap smear;
- cost effectiveness
Many articles concerning conventional Pap smears, ThinPrep® liquid-based cytology (LBC) and Hybrid-Capture II HPV test (HC II) have been published. This study, carried out by the French Society of Clinical Cytology, may be conspicuous for several reasons: it was financially independent; it compared the efficiency of the conventional Pap smear and LBC, of the conventional Pap smear and HC II, and included an economic study based on real costs; for all the women, a “gold standard” reference method, colposcopy, was available and biopsies were performed whenever a lesion was detected; The conventional Pap smear, the LBC (split-sample technique), the colposcopy, and the biopsies were done at the same time. This study included 2,585 women shared into two groups: a group A of a high-risk population, a group B of a screening population. The statistical analysis of the results showed that conventional Pap smears consistently had superior or equivalent sensitivity and specificity than LBC for the lesions at threshold CIN-I (Cervical Intraepithelial Neoplasia) or CIN-II or higher. It underlined the low specificity of the HC II. Finally, the LBC mean cost was never covered by the Social Security tariff. Diagn. Cytopathol. 2005;33:338–343. © 2005 Wiley-Liss, Inc.