Improvement of diagnostic accuracy and screening conditions with liquid-based cytology
Article first published online: 13 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 34, Issue 11, pages 780–785, November 2006
How to Cite
Schledermann, D., Ejersbo, D., Hoelund, B. (2006), Improvement of diagnostic accuracy and screening conditions with liquid-based cytology. Diagn. Cytopathol., 34: 780–785. doi: 10.1002/dc.20515
- Issue published online: 13 OCT 2006
- Article first published online: 13 OCT 2006
- Manuscript Accepted: 23 JAN 2006
- Manuscript Received: 17 OCT 2005
- cervical cytology;
- liquid-based cytology;
- conventional Papanicolaou smear;
The aim of this population-based study was to compare the histological follow-up diagnoses of cervicocytological neoplasia (dysplasia, carcinoma in situ and carcinoma) in conventional Papanicolaou (CP) smear and ThinPrep® PapTest™ samples (TP).
All cytological samples from the County of Funen, Denmark, in the periods 2000 (n = 34,832) and 2002 (n = 29,995) were included in the study. In 2000 and 2002, the specimens were CP and TP, respectively. The detection rate of ≥ mild dysplasia was 0.8% in CP and 1.4% in TP, showing a 75% increase in TP when compared with CP (p < 0.001). Histological follow-up of ≥ moderate dysplasia revealed a neoplastic lesion in 77.1% and 87.9% in CP and TP, respectively (P < 0.001).
The present study indicates that the diagnostic accuracy of cervical cytology is improved with liquid-based cytology. In addition, we focus on the optimized cellular material that shows the diagnostic details very clearly to the microscopist and leads to radically improved screening conditions. Diagn. Cytopathol. 2006;34: 780–785. © 2006 Wiley-Liss, Inc.